A relative of mine just recently landed a decent job in a slumping economy. I had a brief discussion with him about job hunting and his interview process and the following is the one main tip he gave me. Stay Positive. No matter what circumstances you find yourself in financially you need to maintain a positive outlook while interviewing.
If you have been unemployed for a long period of time focus on polishing your skills involving computer skills. Find an computer book that teaches you a new set of skills involving an interesting program and add it to your resume as computer training. This is an affordable way to work through some additional qualifications.
The main point here is to focus on the positive. Positive things happen to positive people. Opportunities do not go away - they go to other people. So - stay active and positive in hunting for your next job.